Does Creatine Break a Fast? The Ultimate Guide to Creatine Supplementation During Fasting

If you’re someone who practices intermittent fasting and wants to optimize your workout performance, you might be wondering whether creatine supplementation breaks a fast.

In this article, we’ll dive deep into the world of creatine, how it functions during fasting, and answer some common questions about taking creatine while fasting, using scientific research and statistics to back our claims.

Our goal is to provide you with a comprehensive understanding of creatine and fasting, so you can make informed decisions about whether to include creatine in your fasting routine.

Quick Overview of What Creatine Is

Creatine is a naturally occurring compound found in our muscles and brain. It’s produced in the body and obtained from certain foods, such as red meat and fish.

Creatine supplements, like creatine monohydrate, are popular among athletes and fitness enthusiasts for their performance-enhancing effects.

Related: What is Creatine?

How does creatine work in the body?

Creatine works by helping to replenish adenosine triphosphate (ATP) stores in muscle cells. ATP is the primary energy source for short, high-intensity activities like weightlifting and sprinting.

When you exercise, your muscles use ATP for energy, which gets depleted quickly.

Creatine supplementation helps restore ATP levels, allowing you to maintain optimal performance during your workouts.

The Role of Creatine in Energy Production

Creatine plays a vital role in energy production, specifically in short, high-intensity activities. By replenishing ATP stores in muscle cells, creatine can lead to increased strength, power, and muscle mass.

Creatine is a natural compound found in our body and in certain foods, aiding in energy production during high-intensity activities. It’s popular among athletes and gym-goers for its performance-enhancing effects.

What is Fasting and its Benefits

Intermittent fasting and various fasting methods

Intermittent fasting and various fasting methods Intermittent fasting is a popular eating pattern that cycles between periods of eating and fasting.

There are several methods of intermittent fasting, such as the 16/8 method (fasting for 16 hours and eating during an 8-hour window) or the 5:2 method (eating normally for five days a week and restricting calories for two days).

Health Benefits of Fasting

Fasting offers numerous health benefits, including weight loss, improved insulin sensitivity, reduced inflammation, and increased cellular repair processes like autophagy.

Fasting and weight loss

Fasting can be an effective weight loss strategy, as it helps create a calorie deficit and enhances fat oxidation.

A 2014 review of studies found that intermittent fasting can lead to a 3-8% weight loss over a period of 3-24 weeks(1).

Fasting refers to the practice of abstaining from food for specific periods, offering benefits such as weight loss, improved metabolic health, and increased longevity.

How does creatine work during fasting?

Effects of creatine on metabolism during fasting

During fasting, your body undergoes several metabolic changes, such as reduced insulin levels and increased fat oxidation.

Creatine supplementation does not significantly impact these metabolic changes or disrupt the fasting state, as it does not affect insulin levels or blood sugar.

Impact on insulin levels and the fasting state

Creatine does not have a significant impact on insulin levels or blood sugar, making it a suitable supplement to take during fasting.

In fact, since creatine can help maintain muscle energy levels and support brain function, it can be an advantageous addition to your fasting routine.

A study conducted in 2011 showed that creatine supplementation had no significant effect on glucose and insulin concentrations(2).

Creatine’s influence on autophagy during fasting

Autophagy, a process that cleans up damaged cells and cellular waste, is enhanced during fasting.

Creatine does not appear to interfere with autophagy; however, more research is needed to fully understand the interaction between creatine and autophagy during fasting.

Creatine helps maintain muscle strength and energy during fasting by replenishing ATP levels, which allows the body to maintain high-intensity activities without breaking the fast.

Advantages of Creatine During your Fasting Period

Maintaining muscle mass and strength

Fasting can sometimes lead to muscle breakdown, but creatine can help counteract this by promoting muscle protein synthesis and reducing muscle damage.

A study conducted on resistance-trained individuals found that creatine supplementation resulted in a significant increase in muscle strength and lean body mass(3).

Enhanced cognitive function

Creatine has cognitive benefits, which can be particularly helpful during fasting periods when mental clarity and focus are crucial.

Research has shown that creatine supplementation can improve cognitive performance in tasks that require short-term memory and quick thinking(4).

Improved Exercise Performance

Creatine helps maintain optimal performance during your fast, allowing you to push harder during your workouts and make the most of your time in the gym.

A meta-analysis of 22 studies concluded that creatine supplementation increased strength and power in resistance training by 5-15%(5).

Support for Metabolic Health

Creatine may also support metabolic health during fasting by enhancing insulin sensitivity and glucose uptake in muscle cells.

While more research is needed in this area, some studies suggest that creatine supplementation may improve glycemic control in type 2 diabetes patients(6).

Creatine during fasting supports muscle mass maintenance, enhanced cognitive function, improved exercise performance, and metabolic health.

Potential side effects or precautions when taking creatine during fasting

Dehydration Risks and the Importance of Hydration

Creatine can cause an initial increase in water weight due to its effect on muscle cells’ water content.

While this is not harmful, it’s crucial to stay well-hydrated during fasting periods to avoid dehydration.

Gastrointestinal Discomfort

Some individuals may experience gastrointestinal discomfort, such as bloating or cramping, when taking creatine during fasting.

To minimize these side effects, consider starting with a lower dose and gradually increasing it, or taking creatine with a small amount of food during your eating window.

Individual Response and Considerations

The effectiveness of creatine supplementation may vary from person to person. Genetic factors, muscle fiber composition, and baseline creatine levels can influence an individual’s response to creatine supplementation.

It’s essential to monitor your progress and adjust your approach accordingly.

The Role of Electrolytes and Minerals

When fasting, it’s crucial to maintain proper electrolyte and mineral balance.

Creatine supplementation may affect electrolyte levels, so ensure you’re consuming adequate amounts of sodium, potassium, magnesium, and calcium during your eating window.

Taking creatine during fasting may cause dehydration and gastrointestinal discomfort, so it’s essential to stay hydrated and be mindful of individual responses and electrolyte balance.

How to take creatine while fasting

Timing of Creatine Supplementation

To avoid any potential interference with your fasting state, consider taking creatine during your eating window, especially if you’re concerned about insulin response or digestion.

Dosage Recommendations

The standard creatine dosage is 5 grams per day, which can be taken all at once or split into smaller doses throughout the day.

Some individuals may benefit from a “loading phase,” where they consume 20 grams of creatine per day for five days to saturate muscle stores quickly, followed by a maintenance dose of 5 grams per day.

Tips for Maximizing Benefits During Fasting

To maximize the benefits of creatine during fasting, ensure you’re consuming adequate protein during your eating window to support muscle growth and repair.

Additionally, focus on high-quality sleep and stress management, as these factors can also affect your training performance and recovery.

Creatine forms and their differences

There are several forms of creatine available, including creatine monohydrate, creatine hydrochloride, and creatine ethyl ester.

Creatine monohydrate is the most researched and widely used form, but some individuals may prefer other forms due to differences in solubility or absorption rates.

While creatine monohydrate is generally the most cost-effective and reliable option, you may wish to experiment with different forms to determine which one works best for you.

Optimal creatine supplementation during fasting involves proper timing, dosing, and consideration of creatine forms to maximize its benefits.

Creatine and fasting: common misconceptions

One common myth is that creatine supplementation will break a fast.

However, as mentioned earlier, creatine does not significantly impact insulin levels or blood sugar, making it a suitable supplement to take during fasting.

As with any dietary or exercise approach, it’s essential to recognize that individual responses to creatine and fasting may vary.

Be open to experimentation and listen to your body to determine the best approach for your unique needs and goals.

Misconceptions about creatine and fasting include the belief that creatine will always break a fast, when in reality, it depends on the individual’s response and the type of fast being practiced.


Will creatine break my fast?

No, creatine does not break a fast, as it does not significantly impact insulin levels or blood sugar. However, to be on the safe side, you can take creatine during your eating window.

Can I take creatine on an empty stomach?

Yes, you can take creatine on an empty stomach. Some people may experience gastrointestinal discomfort, in which case it’s recommended to take creatine with a small amount of food during your eating window.

Is it better to take creatine before or after breaking my fast?

There is no definitive answer to this, as individual responses may vary. However, taking creatine during your eating window can help ensure that it doesn’t interfere with your fasting state.

What other supplements can be taken during fasting?

Supplements like electrolytes, vitamins, minerals, and branched-chain amino acids (BCAAs) can be taken during fasting, but be cautious of supplements that contain calories or may spike insulin levels.

The Bottomline

In summary, creatine is a beneficial supplement for those practicing intermittent fasting, as it does not break a fast and can support muscle mass, strength, cognitive function, and exercise performance.

While some precautions and considerations should be taken into account, such as hydration and electrolyte balance, creatine can be a valuable addition to your fasting routine.

To get the most out of creatine supplementation during fasting, consider taking creatine during your eating window, staying well-hydrated, and monitoring your electrolyte and mineral intake.

Experiment with different forms of creatine and dosage protocols to find what works best for you.

As always, it’s essential to consult with your healthcare professional before starting any new supplement or dietary regimen, especially if you have pre-existing health conditions or concerns.


  1. Varady, K. A. (2011). Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss? Obesity reviews, 12(7), e593-e601.
  2. Gualano, B., DE Salles Painneli, V., Roschel, H., Artioli, G. G., Neves, M., De Sá Pinto, A. L., … & Lancha, A. H. (2011). Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Medicine and Science in Sports and Exercise, 43(5), 770-778.
  3. Kreider, R. B. (2003). Effects of creatine supplementation on performance and training adaptations. Molecular and cellular biochemistry, 244(1-2), 89-94.
  4. Rae, C., Digney, A. L., McEwan, S. R., & Bates, T. C. (2003). Oral creatine monohydrate supplementation improves brain performance: a double–blind, placebo–controlled, cross–over trial. Psychopharmacology, 167(3), 324-329.
  5. Rawson, E. S., & Volek, J. S. (2003). Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. Journal of Strength and Conditioning Research, 17(4), 822-831.
  6. Gualano, B., Macedo, A. R., Alves, C. R., Roschel, H., Benatti, F. B., Takayama, L., … & Pereira, R. M. (2012). Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial. Experimental Gerontology, 47(5), 373-380.

Shopping cart